In a shocking revelation, the Los Angeles County Medical Examiner’s office disclosed that the untimely passing of the beloved “Friends” luminary, Matthew Perry, in October was the result of an accident. What is ketamine? and how did Matthew Perry died?. The cause was attributed to “the acute effects of ketamine,” with drowning, coronary artery disease, and the impacts of buprenorphine listed as contributing factors.

Ketamine and Matthew Perry's death-Digitaltechradar

The Mysterious Circumstances Surrounding Perry’s Death

How did Matthew Perry died?

Perry was discovered in an unresponsive state, face-down in the “heated end” of his pool on Oct. 28. Responders arrived at his Pacific Palisades residence at 4:07 p.m., finding him unconscious in a stand-alone jacuzzi. Despite efforts to save him, Perry had already succumbed before their arrival.

The Role of Ketamine: A Closer Look

The autopsy revealed that Perry, a 54-year-old male with a history of various health conditions, had elevated levels of ketamine in his system. Despite receiving ketamine infusion therapy for depression and anxiety, the report highlighted that the ketamine concentration at the time of death could not be attributed to the therapy, raising questions about the mode of intake.

Understanding Ketamine: More Than an Anesthetic

Repercussions of Ketamine

Ketamine, an FDA-approved anesthetic, gained recognition for its rapid-acting antidepressant effects. Dr. Nolan Williams from Stanford University explained that ketamine’s impact on mood remains uncertain, targeting the neurotransmitter glutamate and potentially influencing enduring lifestyle patterns.

What is ketamine?

Ketamine Misuse and ‘Special K’

While ketamine can serve as a sedative or depression remedy, it also holds a dark side as a “club drug” known as “Special K,” inducing dissociative sensations and hallucinations.

It’s crucial to note the FDA’s role in approving ketamine for certain medical uses. In 2019, the FDA officially sanctioned esketamine, a derivative of ketamine, in the form of a nasal spray for the treatment of depression. This marked a significant milestone, acknowledging the potential benefits of ketamine in addressing mental health issues.

Ketamine Therapy: A Glimpse into Treatment

What Transpires During Ketamine Therapy?

Dr. Amanda Itzkoff sheds light on ketamine therapy, detailing sessions that vary for each patient. Administered intranasally, patients undergo altered, trancelike experiences lasting one to two hours, often accompanied by guided talk therapy.

Was Matthew Perry sober ?

Despite Perry’s struggles with alcohol and drugs, his autopsy revealed no traces of substances like methamphetamine, cocaine, or heroin. Perry, as chronicled in his 2022 memoir, was committed to overcoming his challenges.


Matthew Perry’s untimely demise sheds light on the complexities surrounding mental health treatments like ketamine therapy. While the exact circumstances remain mysterious, it serves as a poignant reminder of the delicate balance individuals face when seeking unconventional methods for mental well-being. As we reflect on Perry’s life and struggles, it prompts a broader conversation about mental health and the evolving landscape of treatments in the modern era.